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Protein Biophysics (Prof. Daniel Otzen)

Daniel Otzen

Professor Interdisciplinary Nanoscience Center - INANO-MBG, iNANO-huset
Group members
Research funding

Research focus in brief

Our research activities fall within 3 main areas, which all relate to the study of the kinetics and thermodynamics of protein conformational changes, namely membrane protein folding, protein-detergent interactions and protein fibrillation. These areas are linked by a keen interest in understanding the mechanistic and thermodynamic behaviour of proteins in different circumstances by quantifying the strength of internal side-chain interactions as well as contacts with solvent molecules, whether it be detergents, denaturants, stabilizing salts and osmolytes or lipids. Ultimately we hope this will lead to a greater manipulative ability vis-a-vis processes of both basic, pharmaceutical and industrial relevance. The general approach is to use available spectroscopic techniques (fluorescence, CD, stopped-flow, FTIR, NMR and dynamic and static light scattering) to generate data which can be analyzed in a quantitative manner to develop models and mechanisms for conformational changes at the molecular level.  

News

Carlsberg Foundation awards A total of DKK 11,7 million to researchers currently and formerly affiliated with iNANO. (Image by Carlsberg Foundation)

2019.11.28 | iNano

6 current and former iNANO researchers receive grants from the Carlsberg Foundation

A total of DKK 11,7 million have been awarded by the Carlsberg Foundation to researchers currently or formerly affiliated with Interdisciplinary Nanoscience Center (iNANO) at Aarhus University.

Nina Kølln Wittig, receives award for best oral presentation at the conference ”Bioinspired Materials: from understanding, through processing, to replication”. (Private photo by courtesy of Nina Kølln Wittig)
Award for best oral presentation to PhD student Nina Kølln Wittig at, October 2019.(Private photo by courtesy of Nina Kølln Wittig)

2019.11.20 | iNano

Award for best oral presentation to Nina Wittig Kølln

PhD student in Associate Professor Henrik Birkedals research group, Nina Kølln Wittig, receives award for best oral presentation at the conference ”Bioinspired Materials: from understanding, through processing, to replication”.

Professor Liv Hornekær will lead the new basic research center InterCat. She is a pioneer in the new interdisciplinary research field of astrochemistry. Photo: Lars Kruse, AU Photo

2019.10.24 | iNano

New centre to find the origins of life in space

With DKK 67.4 million (EUR 8.9 mill.) from the Danish National Research Foundation, professor Liv Hornekær at Aarhus University will establish Center for Interstellar Catalysis, in order to find out how and when the building blocks of life formed in the universe.

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