Our research activities fall within 3 main areas, which all relate to the study of the kinetics and thermodynamics of protein conformational changes, namely membrane protein folding, protein-detergent interactions and protein fibrillation. These areas are linked by a keen interest in understanding the mechanistic and thermodynamic behaviour of proteins in different circumstances by quantifying the strength of internal side-chain interactions as well as contacts with solvent molecules, whether it be detergents, denaturants, stabilizing salts and osmolytes or lipids. Ultimately we hope this will lead to a greater manipulative ability vis-a-vis processes of both basic, pharmaceutical and industrial relevance. The general approach is to use available spectroscopic techniques (fluorescence, CD, stopped-flow, FTIR, NMR and dynamic and static light scattering) to generate data which can be analyzed in a quantitative manner to develop models and mechanisms for conformational changes at the molecular level.
2019.12.19 | iNano
Associate Professor Menglin Chen has received a major grant from the Carlsberg Foundation to develop a completely new method of regenerating brain and heart cells. The method uses water-based nanofibers coated with organic photovoltaic nanomaterials to create light controlled neural stimulating scaffolds inside the body.
2019.12.13 | iNano
A scientific collaboration led by researchers at iNANO/Department of Molecular Biology and Genetics at Aarhus University and the Department of Chemistry at the University of Copenhagen has resulted in the construction of a synthetic DNA nanopore capable of selectively translocating protein-size macromolecules across lipid bilayers.
2019.12.10 | iNano
The Lundbeck Foundation is awarding grants worth DKK 232 million (USD 34 million) to six leading neuroscientists. The LF Professorships programme is the Foundation’s largest grant allocation to date.
