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Protein Biophysics (Prof. Daniel Otzen)

Daniel Otzen

Professor Interdisciplinary Nanoscience Center - INANO-MBG, iNANO-huset
Group members
Research funding

Research focus in brief

Our research activities fall within 3 main areas, which all relate to the study of the kinetics and thermodynamics of protein conformational changes, namely membrane protein folding, protein-detergent interactions and protein fibrillation. These areas are linked by a keen interest in understanding the mechanistic and thermodynamic behaviour of proteins in different circumstances by quantifying the strength of internal side-chain interactions as well as contacts with solvent molecules, whether it be detergents, denaturants, stabilizing salts and osmolytes or lipids. Ultimately we hope this will lead to a greater manipulative ability vis-a-vis processes of both basic, pharmaceutical and industrial relevance. The general approach is to use available spectroscopic techniques (fluorescence, CD, stopped-flow, FTIR, NMR and dynamic and static light scattering) to generate data which can be analyzed in a quantitative manner to develop models and mechanisms for conformational changes at the molecular level.  

News

Jørgen Kjems (left) og Morten T. Venø describes in an article in PNAS, how expression of non-coding RNA changes during epileptic seizures in rodents (Photo: Anne Færch Nielsen)

2020.06.25 | iNano

Large-scale data sets identify small RNAs with a role in epilepsy

A new paper from Jørgen Kjems' group at iNANO and MBG describes how expression of non-coding RNA changes during epileptic seizures in rodents. The authors found that inhibiting a specific set of microRNAs (miRNAs) by antisense technology reduced seizure frequency in a mouse model, suggesting that these RNA molecules could serve as possible targets…

(ill: Tilman Grünewald)

2020.06.15 | iNano

3D X-ray reveals secrets from inside bones

An international research team has used new X-ray techniques to describe how the architecture of healthy human bones is built up. The team has uncovered a hitherto unknown structure in healthy bones.

A project team from Aarhus University and Fida Biosystems will use advanced microfluidic techniques in the search for compounds, which can block the contact between SARS-CoV-2 virus and receptors on human cells. Click on the graphic to see it full size. (Graphics by Daniel Otzen)
Daniel Otzen is heading a collaborative project with DKK 3.8 million from the Innovation Fund Denmark for combating COVID-19. Photo: Jesper Rais, AU.

2020.05.29 | iNano

DKK 3.8 million for collaboration on fighting COVID-19

Daniel Otzen and collaborators, Jørgen Kjems and Victoria Birkedal from the Interdisciplinary Nanoscience Center (iNANO) and the company Fida Biosystems, have received DKK 3.8 million from the Innovation Fund Denmark to develop a screening system to identify drugs that are able to combat COVID-19.

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