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Protein Biophysics (Prof. Daniel Otzen)

Daniel Otzen

Professor Interdisciplinary Nanoscience Center - INANO-MBG, iNANO-huset
Group members
Research funding

Research focus in brief

Our research activities fall within 3 main areas, which all relate to the study of the kinetics and thermodynamics of protein conformational changes, namely membrane protein folding, protein-detergent interactions and protein fibrillation. These areas are linked by a keen interest in understanding the mechanistic and thermodynamic behaviour of proteins in different circumstances by quantifying the strength of internal side-chain interactions as well as contacts with solvent molecules, whether it be detergents, denaturants, stabilizing salts and osmolytes or lipids. Ultimately we hope this will lead to a greater manipulative ability vis-a-vis processes of both basic, pharmaceutical and industrial relevance. The general approach is to use available spectroscopic techniques (fluorescence, CD, stopped-flow, FTIR, NMR and dynamic and static light scattering) to generate data which can be analyzed in a quantitative manner to develop models and mechanisms for conformational changes at the molecular level.  


Skrydstrup group, part of the RePURpose project, develops effective method for deconstruction of polyurethane (PU) by using a catalyst based on Manganese, an earth-abundant metal. (Illustr.: ChemSusChem, Sep 12, 2021)
The new method for recycling polyurethane (PU) is based on a first row transition metal catalyst, a green and cheap base, and a green solvent. (Illustr.: Lise R. L. Pedersen)

2021.10.01 | iNano

Effective deconstruction of PU by catalyst based on earth-abundant metal

Polyurethane (PU) is a widely used material in a countless number of everyday products as well as more sophisticated objects like aircrafts. Unfortunately, there are very few methods to reuse or recycle PU and when recycled, the product often loses its original properties. Researchers at Aarhus University are working tirelessly on establishing a…

Professors Troels Skrydstrup and Kim Daasbjerg participates in the new Novo Nordisk Foundation CO2 Research Center. (Photo: Lars Kruse, AU Photo)

2021.09.23 | iNano

New research centre to help solve the climate crisis

Professors Troels Skrydstrup and Kim Daasbjerg participate in a new, unique research centre, which has just been launched. The Novo Nordisk Foundation CO2 Research Center is established with a grant of DKK 630 million from the Novo Nordisk Foundation (NNF) and based at Aarhus University. The new centre will ensure cross-disciplinary collaboration…

Professor Jeppe Vang Lauritsen, Professor Kurt Gothelf, and Professor Torben René Jensen have been granted a Villum Experiment Grant of DKK 2 million. (Photos: Lars Kruse and Maria Randima, AU Photo)

2021.09.15 | iNano

Grants for research projects that challenge the norm

Congratulations to Professor Jeppe Vang Lauritsen, Professor Kurt Gothelf, Professor Torben René Jensen, and all the other researchers at Faculty of Natural Sciences, who each have been granted a Villum Experiment Grant of DKK 2 million. Lauritsen, Gothelf, and Jensen will investigate topological insulators in electrocatalytic reactions, small…

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