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Protein Biophysics (Prof. Daniel Otzen)

Daniel Otzen

Professor Interdisciplinary Nanoscience Center - INANO-MBG, iNANO-huset
Group members
Research funding

Research focus in brief

Our research activities fall within 3 main areas, which all relate to the study of the kinetics and thermodynamics of protein conformational changes, namely membrane protein folding, protein-detergent interactions and protein fibrillation. These areas are linked by a keen interest in understanding the mechanistic and thermodynamic behaviour of proteins in different circumstances by quantifying the strength of internal side-chain interactions as well as contacts with solvent molecules, whether it be detergents, denaturants, stabilizing salts and osmolytes or lipids. Ultimately we hope this will lead to a greater manipulative ability vis-a-vis processes of both basic, pharmaceutical and industrial relevance. The general approach is to use available spectroscopic techniques (fluorescence, CD, stopped-flow, FTIR, NMR and dynamic and static light scattering) to generate data which can be analyzed in a quantitative manner to develop models and mechanisms for conformational changes at the molecular level.  

News

"Humanity is facing a huge problem in relation to both climate change and limited carbon-based resources. We need to find other sources of carbon," says Associate Professor Nina Lock, who's received a generous grant from the Carlsberg Foundation for her new project. Photo: AU Foto.

2019.12.10 | iNano

Metal-organic sponge to convert CO2 into fuel

Associate Professor Nina Lock from the Department of Engineering and iNANO associated has received a grant of DKK 4.3 million (EUR 0.6 mill.) from the Carlsberg Foundation to develop an entirely new material which, through electrocatalysis, can transform CO2 into useful products.

CADIAC researchers highlights important recent discovery published in Nature.

2019.12.05 | CADIAC

Molecular catalysts with great prospects for use in converting CO2

Assist. Prof. Xinming Hu and Prof. Kim Daasbjerg from Carbon Dioxide Axtivation Center (CADIAC) at Aarhus University describe the state-of-the-art of the electrochemical CO2 reduction promoted by molecular catalysts and discuss an important recent discovery published in Nature. Read the Nature News & Views article by Hu and Daasbjerg here.

iNANO researchers, Line Debois Frejlev Nielsen (middle) and Malthe Hansen-Bruhn (left), won the Bioinnovation Institute (BII) Acceleration Award at BII DemoDAY 2019. Jens Nielsen (right) is Chief Executive Officer at BII. (Photo: Esben Zøllner Olesen)

2019.11.29 | iNano

iNANO researchers honored with business acceleration award

The discovery of a unique technology to detect small molecules in blood, and the potential of being able to secure a more correct and safe treatment of certain patients, led iNANO researchers to establish the startup company, MedicQuant. The team behind the company has just won the Bioinnovation Institute (BII) Acceleration Award.

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