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Protein Biophysics (Prof. Daniel Otzen)

Daniel Otzen

Professor Interdisciplinary Nanoscience Center - INANO-MBG, iNANO-huset
Group members
Research funding

Research focus in brief

Our research activities fall within 3 main areas, which all relate to the study of the kinetics and thermodynamics of protein conformational changes, namely membrane protein folding, protein-detergent interactions and protein fibrillation. These areas are linked by a keen interest in understanding the mechanistic and thermodynamic behaviour of proteins in different circumstances by quantifying the strength of internal side-chain interactions as well as contacts with solvent molecules, whether it be detergents, denaturants, stabilizing salts and osmolytes or lipids. Ultimately we hope this will lead to a greater manipulative ability vis-a-vis processes of both basic, pharmaceutical and industrial relevance. The general approach is to use available spectroscopic techniques (fluorescence, CD, stopped-flow, FTIR, NMR and dynamic and static light scattering) to generate data which can be analyzed in a quantitative manner to develop models and mechanisms for conformational changes at the molecular level.  

News

Professor Frans Mulder and coworkers at Aarhus University and the University of Florence have developed a way to improve the interpretation of hydrogen exchange data. (Illustr.: Biophys J, 120, 1-8, September (2021), Photo: private)

2021.09.09 | iNano

A better model for the interpretation of protein hydrogen exchange data

When studying stability and folding of proteins hydrogen exchange substitution is a very important technique. However, the interpretation of the data is complicated by electrostatic effects and the magnitude of these has not been accounted for until now. Mulder et al. have now shown a way to better foretell these effects and thereby provide a key…

Honor to nanoscience student, Cathrine Abild Meyer, from Brigitte Städler’s group. She and four other AU students will receive the HM Queen Margrethe II Travel Grant 2021.

2021.09.03 | iNano

Honor to nanoscience student in Brigitte Städler’s group

Nanoscience student, Cathrine Abild Meyer has been selected as a strong and promising research talent at Aarhus University. She will receive the HM Queen Margrethe II Travel Grant 2021, which will allow her to go study abroad. Cathrine Abild Meyer is presently a Master's student and earned top marks for her Bachelor's project at Brigitte…

Prof. Emer. Hans Jørgen Jakobsen (Dept. of Chemistry, AU) and Prof. Bo Brummerstedt Iversen (Dept. of Chemistry and iNANO, AU) publish breaking NMR research on MoS2 in ACS J Phys Chem C. Photo: private (HHJ) and Lars Kruse, AU Photo (BBI)

2021.08.19 | iNano

Prof. Bo B. Iversen contributes in publishing breaking NMR research on MoS2

Article published in the ACS Journal of Physical Chemistry C.

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