Aarhus University Seal / Aarhus Universitets segl

Protein Biophysics (Prof. Daniel Otzen)

Daniel Otzen

Professor Interdisciplinary Nanoscience Center - INANO-MBG, iNANO-huset
Group members
Research funding

Research focus in brief

Our research activities fall within 3 main areas, which all relate to the study of the kinetics and thermodynamics of protein conformational changes, namely membrane protein folding, protein-detergent interactions and protein fibrillation. These areas are linked by a keen interest in understanding the mechanistic and thermodynamic behaviour of proteins in different circumstances by quantifying the strength of internal side-chain interactions as well as contacts with solvent molecules, whether it be detergents, denaturants, stabilizing salts and osmolytes or lipids. Ultimately we hope this will lead to a greater manipulative ability vis-a-vis processes of both basic, pharmaceutical and industrial relevance. The general approach is to use available spectroscopic techniques (fluorescence, CD, stopped-flow, FTIR, NMR and dynamic and static light scattering) to generate data which can be analyzed in a quantitative manner to develop models and mechanisms for conformational changes at the molecular level.  


Associate Professor Frans Mulder and coworkers at Aarhus University have developed ODiNPred (Prediction of Order and Disorder by evaluation of NMR data), a software tool developed for prediction of protein order and disorder. (Image: Frans Mulder)

2020.09.08 | iNano

Prediction of protein disorder from amino acid sequence

Structural disorder is vital for proteins’ function in diverse biological processes. It is therefore highly desirable to be able to predict the degree of order and disorder from amino acid sequence. AU researchers have developed a prediction tool by using machine learning together with experimental NMR data for hundreds of proteins, which is…

iNANO associated researcher, Peter Balling, appointed professor of experimental physics at the Department of Physics and Astronomy. (Photo by Lars Kruse, AU Photo)

2020.09.03 | iNano

Peter Balling appointed Professor

Congratulations to Peter Balling, who per. 1 September 2020 has been appointed professor of experimental physics at the Department of Physics and Astronomy at Aarhus University.

New work from Jeppe Vang Lauritsens research group shows that some reactant molecules can adsorb on vacancy sites on a MoS2 nanoparticle, despite being too big to fit in such a site. (Graphics: Jeppe Vang Lauritsen)

2020.09.01 | iNano

Room to react: new results with potential to help produce cleaner fuel

New results, with implications for catalysis used for cleaning up crude and bio oils, show that a reactant molecule can generate its own larger active site, when it is adsorbed onto certain vacancy positions on MoS2 nanoparticles. The finding has been published in Nature Communications by the group of Jeppe V. Lauritsen at iNANO, Aarhus University.

Showing results 13 to 15 of 278

Previous 1 2 3 4 5 6 7 8 9 10 Next

Recent publications

Sort by: Date | Author | Title