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Protein Biophysics (Prof. Daniel Otzen)

Daniel Otzen

Professor Interdisciplinary Nanoscience Center - INANO-MBG, iNANO-huset
Group members
Research funding

Research focus in brief

Our research activities fall within 3 main areas, which all relate to the study of the kinetics and thermodynamics of protein conformational changes, namely membrane protein folding, protein-detergent interactions and protein fibrillation. These areas are linked by a keen interest in understanding the mechanistic and thermodynamic behaviour of proteins in different circumstances by quantifying the strength of internal side-chain interactions as well as contacts with solvent molecules, whether it be detergents, denaturants, stabilizing salts and osmolytes or lipids. Ultimately we hope this will lead to a greater manipulative ability vis-a-vis processes of both basic, pharmaceutical and industrial relevance. The general approach is to use available spectroscopic techniques (fluorescence, CD, stopped-flow, FTIR, NMR and dynamic and static light scattering) to generate data which can be analyzed in a quantitative manner to develop models and mechanisms for conformational changes at the molecular level.  

News

Associate Professor Ebbe S. Andersen, Interdisciplinary Nanoscience Center (iNANO) at Aarhus University has received the Danish polymer Prize - ATV | Elastyrenprisen 2021. Chairman of the Prize committee Niels Chr. Nielsen also handed over the prize to Associate Professor Anders Egede Daugaard (DTU). Photo: Tom Jersø

2021.06.22 | iNano

Assoc. Prof. Ebbe S. Andersen honored by the Danish Academy of Technical Sciences

Congratulations to Associate Professor Ebbe S. Andersen who is awarded the Danish polymer prize, Elastyrenprisen 2021, for being an internationally recognized scientist and a pioneer within biopolymer research, including RNA origami. The award is given by the Danish Academy of Technical Sciences (ATV).

Professor Poul Nissen awarded Anders Jahre's major medical award in 2021 for his research in membrane proteins. Photo: Lisbeth Heilesen

2021.06.10 | iNano

Professor Poul Nissen awarded Anders Jahre's large medical award 2021

One of the Nordic region's most prestigious research prizes, the Anders Jahre Prize, goes to Professor Poul Nissen from Aarhus University. Poul Nissen is awarded the prize for his research in the transport of proteins in and out of cells. This knowledge is of great importance for understanding diseases such as cancer, cardiovascular disease and…

Binding site I of SERCA is not conserved in LMCA1. Alignment between LMCA1 G4 E2-BeF3- (red) and SERCA E2-AlF4- (pdb: 3b9r) (dark grey). Relevant Ca2+-coordinating residues are shown as sticks. The structures are aligned by the residues shown as sticks. SERCA Ca2+ binding site I and II are indicated. Figure: Sara Basse Hansen.

2021.06.09 | iNano

Ion and lipid transporters specialize for their niche

Cell viability require that a variety of functions at the cell membrane are maintained properly. P-type ATPases translocate substrates across the membrane, and they have evolved into different types taking care of specific substrates within a diverse range. Now, key structural aspects have been described on how two different types of P-type…

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