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Protein Biophysics (Prof. Daniel Otzen)

Daniel Otzen

Professor Interdisciplinary Nanoscience Center - INANO-MBG, iNANO-huset
Group members
Research funding

Research focus in brief

Our research activities fall within 3 main areas, which all relate to the study of the kinetics and thermodynamics of protein conformational changes, namely membrane protein folding, protein-detergent interactions and protein fibrillation. These areas are linked by a keen interest in understanding the mechanistic and thermodynamic behaviour of proteins in different circumstances by quantifying the strength of internal side-chain interactions as well as contacts with solvent molecules, whether it be detergents, denaturants, stabilizing salts and osmolytes or lipids. Ultimately we hope this will lead to a greater manipulative ability vis-a-vis processes of both basic, pharmaceutical and industrial relevance. The general approach is to use available spectroscopic techniques (fluorescence, CD, stopped-flow, FTIR, NMR and dynamic and static light scattering) to generate data which can be analyzed in a quantitative manner to develop models and mechanisms for conformational changes at the molecular level.  

News

2021.05.10 | iNano

65.5 million DKK from DFF for research at Natural Sciences

The Independent Research Fund Denmark grants DKK 65.5 million for 20 research projects at Natural Sciences. Jeppe Vang Lauritsen, Duncan Sutherland, Jan Skov Pedersen, Mogens Christensen, and Martin Bremholm receive DKK 17 million in total.

Manish Debnath receives DKK 2.4m from the Lundbeck Foundation and will start as a post doc at iNANO, AU. Illustration: Colourbox

2021.05.07 | iNano

DKK 2.4m for developing a method to testing for disease-specific biomarkers

The Lundbeck Foundation has granted Manish Debnath DKK 2.4m, who will come to iNANO in order to work on developing chemically modified aptamers for rapid detection of disease-specific biomarkers. This could help SARS COV-2 testing.

In addition to the honor, Andreas Sommerfeldt received a prize of DKK 50,000. with him home. Press photo: Agnete Schlichtkrull

2021.05.03 | iNano

PhD in Nanoscience wins Ph.D.-Cup 2021

Ph.D. in Nanoscience from the Department of Chemistry and iNANO at Aarhus University, Andreas Sommerfeldt, won the Ph.D.-Cup final, which was broadcasted on DR 2 on Friday 30 April.

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