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Protein Biophysics (Prof. Daniel Otzen)

Daniel Otzen

Professor Interdisciplinary Nanoscience Center - INANO-MBG, iNANO-huset
Group members
Research funding

Research focus in brief

Our research activities fall within 3 main areas, which all relate to the study of the kinetics and thermodynamics of protein conformational changes, namely membrane protein folding, protein-detergent interactions and protein fibrillation. These areas are linked by a keen interest in understanding the mechanistic and thermodynamic behaviour of proteins in different circumstances by quantifying the strength of internal side-chain interactions as well as contacts with solvent molecules, whether it be detergents, denaturants, stabilizing salts and osmolytes or lipids. Ultimately we hope this will lead to a greater manipulative ability vis-a-vis processes of both basic, pharmaceutical and industrial relevance. The general approach is to use available spectroscopic techniques (fluorescence, CD, stopped-flow, FTIR, NMR and dynamic and static light scattering) to generate data which can be analyzed in a quantitative manner to develop models and mechanisms for conformational changes at the molecular level.  

News

Thibaud Dieudonné (photo: Lisbeth Heilesen)

2021.02.25 | iNano

Postdoc in Prof. Poul Nissen's group receives the prestigious Marie Skłodowska-Curie fellowship

Postdoc Thibaud Dieudonné from the Department of Molecular Biology and Genetics at Aarhus University receives the highly prestigious Marie Skłodowska-Curie Individual Fellowship to study how a human lipid transporter is linked to a rare inherited liver disease.

Illustration: Colourbox

2021.02.12 | iNano

Fundings from the Research Infrastructure Pool

Bo Brummerstedt Iversen is head of the SINCRYS project (Single Crystal X-ray Diffraction Side-station at DanMAX). The project receives DKK 25 million for research equipment and facilities.

The Lundbeck Foundation is giving the DANDRITE neuroscience centre at Aarhus University DKK 75 M (EUR 10 M) to spend on research up to 2028. Photo: Colourbox

2021.02.10 | iNano

Grant worth DKK 75 M for neuroscience in Aarhus

The Lundbeck Foundation is giving the DANDRITE neuroscience centre at Aarhus University funding to spend on research up to 2028. The funds worth DKK 75 M (EUR 10 M) will primarily be spent on recruitment of five new DANDRITE group leaders to head individual neuroscience research programmes.

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