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Protein Biophysics (Prof. Daniel Otzen)

Daniel Otzen

Professor Interdisciplinary Nanoscience Center - INANO-MBG, iNANO-huset
Group members
Research funding

Research focus in brief

Our research activities fall within 3 main areas, which all relate to the study of the kinetics and thermodynamics of protein conformational changes, namely membrane protein folding, protein-detergent interactions and protein fibrillation. These areas are linked by a keen interest in understanding the mechanistic and thermodynamic behaviour of proteins in different circumstances by quantifying the strength of internal side-chain interactions as well as contacts with solvent molecules, whether it be detergents, denaturants, stabilizing salts and osmolytes or lipids. Ultimately we hope this will lead to a greater manipulative ability vis-a-vis processes of both basic, pharmaceutical and industrial relevance. The general approach is to use available spectroscopic techniques (fluorescence, CD, stopped-flow, FTIR, NMR and dynamic and static light scattering) to generate data which can be analyzed in a quantitative manner to develop models and mechanisms for conformational changes at the molecular level.  


In addition to the honor, Andreas Sommerfeldt received a prize of DKK 50,000. with him home. Press photo: Agnete Schlichtkrull

2021.05.03 | iNano

PhD in Nanoscience wins Ph.D.-Cup 2021

Ph.D. in Nanoscience from the Department of Chemistry and iNANO at Aarhus University, Andreas Sommerfeldt, won the Ph.D.-Cup final, which was broadcasted on DR 2 on Friday 30 April.

Professor Anja-Verena Mudring has received DKK 40 million for her research from the VILLUM Investigator programme. (Photo: VILLUM FOUNDATION).

2021.04.14 | iNano

DKK 40 million for future nano-technology

Nanomaterials have become indispensable for modern life, and our lives increasingly depend on nanomaterials with defined structures and properties. Professor Anja-Verena Mudring has received a VILLUM Investigator grant of almost DKK 40 million for an upcoming project that will challenge borders so that even more powerful tools to synthesise…

Mingdong Dong and Jeppe Vang Lauritsen have been appointed Professors in Experimental Surface and Interface Science. (Photos by Maria Randima and Lars Kruse, AU Photo)

2021.03.26 | iNano

Professor Appointments

Congratulations to Mingdong Dong and Jeppe Vang Lauritsen who have been appointed Professors in Experimental Surface and Interface Science at the Interdisciplinary Nanoscience Center, Faculty of Natural Sciences, Aarhus University. The appointments are effective as of 1 April 2021.

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