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Protein Biophysics (Prof. Daniel Otzen)

Daniel Otzen

Professor Interdisciplinary Nanoscience Center - INANO-MBG, iNANO-huset
Group members
Research funding

Research focus in brief

Our research activities fall within 3 main areas, which all relate to the study of the kinetics and thermodynamics of protein conformational changes, namely membrane protein folding, protein-detergent interactions and protein fibrillation. These areas are linked by a keen interest in understanding the mechanistic and thermodynamic behaviour of proteins in different circumstances by quantifying the strength of internal side-chain interactions as well as contacts with solvent molecules, whether it be detergents, denaturants, stabilizing salts and osmolytes or lipids. Ultimately we hope this will lead to a greater manipulative ability vis-a-vis processes of both basic, pharmaceutical and industrial relevance. The general approach is to use available spectroscopic techniques (fluorescence, CD, stopped-flow, FTIR, NMR and dynamic and static light scattering) to generate data which can be analyzed in a quantitative manner to develop models and mechanisms for conformational changes at the molecular level.  

News

Unraveling the three-dimensional structure of the glycine transporter, researchers have now come a big step closer to understanding the regulation of glycine in the brain. These result open up opportunities to find effective drugs that inhibit GlyT1 function, with major implications for the treatment of schizophrenia and other mental disorders. Figure: Azadeh Shahsavar

2021.03.04 | iNano

Structure determination of the glycine transporter GlyT1 opens new avenues in development of psychiatric drugs

Glycine can stimulate or inhibit neurons in the brain, thereby controlling complex functions. Unraveling the three-dimensional structure of the glycine transporter, researchers have now come a big step closer to understanding the regulation of glycine in the brain. These results, which have been published in Nature, open up opportunities to find…

Aerial photo: Jørgen Weber

2021.03.03 | iNano

iNANO afiliated researchers receive new grants from the Novo Nordisk Foundation

The Novo Nordisk Foundation has for the first time granted project support earmarked for basic research in the natural sciences and technical disciplines. At the Faculty of Natural Sciences, six researchers, including Birgit Schiøtt and Brian Julsgaard, have received grants totalling just over DKK 17.5 million.

Associate Professor Jørgen Skibsted. (Photo by Lars Kruse, AU Photo)

2021.02.26 | iNano

Climate-friendly cement

Jørgen Skibsted is participating in the Innovation Fund Denmark 'Grand Solutions' project CALLISTE.

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