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Protein Biophysics (Prof. Daniel Otzen)

Daniel Otzen

Professor Interdisciplinary Nanoscience Center - INANO-MBG, iNANO-huset
Group members
Research funding

Research focus in brief

Our research activities fall within 3 main areas, which all relate to the study of the kinetics and thermodynamics of protein conformational changes, namely membrane protein folding, protein-detergent interactions and protein fibrillation. These areas are linked by a keen interest in understanding the mechanistic and thermodynamic behaviour of proteins in different circumstances by quantifying the strength of internal side-chain interactions as well as contacts with solvent molecules, whether it be detergents, denaturants, stabilizing salts and osmolytes or lipids. Ultimately we hope this will lead to a greater manipulative ability vis-a-vis processes of both basic, pharmaceutical and industrial relevance. The general approach is to use available spectroscopic techniques (fluorescence, CD, stopped-flow, FTIR, NMR and dynamic and static light scattering) to generate data which can be analyzed in a quantitative manner to develop models and mechanisms for conformational changes at the molecular level.  


Alexander Zelikin will be appointed as Professor at Dept. of Chemistry on 1 April 2021. (Photo: Lars Kruse, AU Photo)

2021.03.26 | iNano

Professor Appointment

Congratulations to Alexander Zelikin who has been appointed Professor at Department of Chemistry, Faculty of Natural Sciences, Aarhus University. The appointment is effective as of 1 April 2021.

Professor Daniel Otzen and Assistant Professor Alonso Rosas-Hernandez are among the new AIAS Associates. Photo: Jesper Rais (DO), Private (ARH)

2021.03.25 | iNano

Daniel Otzen and Alonso Rosas-Hernández among new AIAS Associates

Congratulations to Professor Daniel Otzen (iNANO and MBG) and Assistant Professor Alonso Rosas-Hernández (CHEM and iNANO) who are among the new AIAS Associates. They will be part of the multidisciplinary environment at Aarhus Institute of Advanced Studies (AIAS) and take part in facilitating and inspiring new interdisciplinary research projects…

iNANO researcher Mingdong Dong reports of filamentous Gram-positive bacterium for long-distance electron transfer in Nature Communications. (Image: Nature Commun 12, Article no. 1709 (2021)
A comparison among the conductive networks of Geobacter, cable bacteria, and L. varians GY32. The newly discovered conductive networks of L. varians GY32 combines the filamentous shape with extracellular nanowire-like appendages to form a new type of network. (Image: Nature Commun 12, Article no. 1709 (2021))
Conductive cellular network of L. varians. A, cellular network contains filamentous cells and nanowires; B, cell and nanowire detected with Kelvin probe force microscopy; C, potential profile along the dashed line in B. (Image adapted from Nature Commun 12, Article no. 1709 (2021))

2021.03.19 | iNano

Filamentous Gram-positive bacterium for long-distance electron

Increasing evidence has demonstrated how the microbial world is electrically connected. Electrical wire networks on the micrometer to centimeter scale have been found in many microorganisms and in diverse environments, where they are believed to play important roles in biogeochemical processes, pollutant degradation and bioenergy recovery. iNANO…

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