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Protein Biophysics (Prof. Daniel Otzen)

Daniel Otzen

Professor Interdisciplinary Nanoscience Center - INANO-MBG, iNANO-huset
Group members
Research funding

Research focus in brief

Our research activities fall within 3 main areas, which all relate to the study of the kinetics and thermodynamics of protein conformational changes, namely membrane protein folding, protein-detergent interactions and protein fibrillation. These areas are linked by a keen interest in understanding the mechanistic and thermodynamic behaviour of proteins in different circumstances by quantifying the strength of internal side-chain interactions as well as contacts with solvent molecules, whether it be detergents, denaturants, stabilizing salts and osmolytes or lipids. Ultimately we hope this will lead to a greater manipulative ability vis-a-vis processes of both basic, pharmaceutical and industrial relevance. The general approach is to use available spectroscopic techniques (fluorescence, CD, stopped-flow, FTIR, NMR and dynamic and static light scattering) to generate data which can be analyzed in a quantitative manner to develop models and mechanisms for conformational changes at the molecular level.  

News

Steen Uttrup Pedersen and Kim Daasbjerg are cofounders of RadiSurf, a spin-out from Department of Chemistry and Interdisciplinary Nanoscience Center (iNANO) which has been acquired for triple-digit million amount. (Photo: Lars Kruse, AU Photo)

2021.05.19 | iNano

Spin-out tech-company from Aarhus University acquired for triple-digit million amount

An investment fund have acquired and invested over DKK 100 million in the tech-company, RadiSurf, a spin-out from Department of Chemistry and iNANO. This will make it possible to scale the production to supply world’s largest industries.

Skrydstrup Group at iNANO & Dept. of Chemistry (AU) participate in new partnership with industry in creating fully recyclable wind turbines. Illustration: Colourbox

2021.05.17 | iNano

New coalition of industry and academia to commercialise solution for full recyclability of wind turbine blades

A new partnership between Skrydstrup Group (iNANO & Dept. of Chemistry, Aarhus University), Vestas, Olin, and the Danish Technological Institute collides industry and research to support circularity of wind turbine blades. The CETEC project paves the way for manufacturing new blades using materials from old turbine blades, thereby creating fully…

PhD Alexander Sandahl, together with Professor Kurt Gothelf, Professor Troels Skrydstrup and a number of students in the groups, has developed a method for efficient and automated production of ingredients for DNA synthesis. (Illustration: Colourbox)
Schematic overview of strategy for synthesis of phosphoramidites in a flow-based setup. (Illustration: Nature Commun 12, Artikel nr. 2760 (2021))

2021.05.10 | iNano

New method for producing synthetic DNA

Chemically synthesized short DNA sequences are extremely important ingredients with countless uses in research laboratories, hospitals, and in industry, like in the method for identifying COVID-19. Phosphoramidites are necessary building blocks in the production of DNA sequences, but they are unstable, and break quickly. PhD Alexander Sandahl…

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