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Protein Biophysics (Prof. Daniel Otzen)

Daniel Otzen

Professor Interdisciplinary Nanoscience Center - INANO-MBG, iNANO-huset
Group members
Research funding

Research focus in brief

Our research activities fall within 3 main areas, which all relate to the study of the kinetics and thermodynamics of protein conformational changes, namely membrane protein folding, protein-detergent interactions and protein fibrillation. These areas are linked by a keen interest in understanding the mechanistic and thermodynamic behaviour of proteins in different circumstances by quantifying the strength of internal side-chain interactions as well as contacts with solvent molecules, whether it be detergents, denaturants, stabilizing salts and osmolytes or lipids. Ultimately we hope this will lead to a greater manipulative ability vis-a-vis processes of both basic, pharmaceutical and industrial relevance. The general approach is to use available spectroscopic techniques (fluorescence, CD, stopped-flow, FTIR, NMR and dynamic and static light scattering) to generate data which can be analyzed in a quantitative manner to develop models and mechanisms for conformational changes at the molecular level.  

News

Alexander Zelikin receives 13.5m from Novo Nordisk Foundation for signalling and internalising receptor mimics. (Photo: Lars Kruse, AU Photo)

2020.06.25 | iNano

The Novo Nordisk Foundation supports wild scientific and technical research ideas

For the first time, the Novo Nordisk Foundation has awarded grants within the research programme NERD, which is targeted at ambitious and wild research ideas in the fields of scientific and technical research. At Aarhus University, Associate Professor Alexander Zelikin has just received DKK 13.5 million.

Jørgen Kjems (left) og Morten T. Venø describes in an article in PNAS, how expression of non-coding RNA changes during epileptic seizures in rodents (Photo: Anne Færch Nielsen)

2020.06.25 | iNano

Large-scale data sets identify small RNAs with a role in epilepsy

A new paper from Jørgen Kjems' group at iNANO and MBG describes how expression of non-coding RNA changes during epileptic seizures in rodents. The authors found that inhibiting a specific set of microRNAs (miRNAs) by antisense technology reduced seizure frequency in a mouse model, suggesting that these RNA molecules could serve as possible targets…

(ill: Tilman Grünewald)

2020.06.15 | iNano

3D X-ray reveals secrets from inside bones

An international research team has used new X-ray techniques to describe how the architecture of healthy human bones is built up. The team has uncovered a hitherto unknown structure in healthy bones.

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