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Protein Biophysics (Prof. Daniel Otzen)

Daniel Otzen

Professor Interdisciplinary Nanoscience Center - INANO-MBG, iNANO-huset
Group members
Research funding

Research focus in brief

Our research activities fall within 3 main areas, which all relate to the study of the kinetics and thermodynamics of protein conformational changes, namely membrane protein folding, protein-detergent interactions and protein fibrillation. These areas are linked by a keen interest in understanding the mechanistic and thermodynamic behaviour of proteins in different circumstances by quantifying the strength of internal side-chain interactions as well as contacts with solvent molecules, whether it be detergents, denaturants, stabilizing salts and osmolytes or lipids. Ultimately we hope this will lead to a greater manipulative ability vis-a-vis processes of both basic, pharmaceutical and industrial relevance. The general approach is to use available spectroscopic techniques (fluorescence, CD, stopped-flow, FTIR, NMR and dynamic and static light scattering) to generate data which can be analyzed in a quantitative manner to develop models and mechanisms for conformational changes at the molecular level.  

News

Malthe von Tangen Sivertsen is the first student to complete the Nanoscience Challenge Programme. (Photo: Jeppe Vang Lauritsen)

2019.10.08 | iNano

First Nanoscience Challenge student

Congratulations to Nanoscience student Malthe von Tangen Sivertsen, who is the first student to have completed the challenge program in nanoscience at Interdisciplinary Nanoscience Center, Aarhus University.

Associate Professor Rikke Louise Meyer and Postdoc Chengfang Pang receives VILLUM Experiment grants. Image: VILLUM FONDEN

2019.09.10 | iNano

VILLUM FONDEN awards DKK 4 million for bold experiments at Interdisciplinary Nanoscience Center

Congratulations to Associate Professor Rikke Louise Meyer (iNANO) for receiving a Villum Experiment grant. Also Postdoc Chengfang Pang has been awarded approx. DKK 2 million to carry out research at iNANO.

The four molecular biologists behind the spin-out company omiics (from left): Yan Yan, Morten Venø, Junyi Su and Susanne Venø (photo: Kenneth Frydensbjerg)

2019.09.09 | iNano

Molecular biologists are successful with spin-out company

Four molecular biologists from Aarhus University have started a spin-out company that offers to identify very small differences between biological samples with a special technique. The researchers build on the experience they gained when they were students and postdocs at the Department of Molecular Biology and Genetics/iNANO with a special…

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