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Protein Biophysics (Prof. Daniel Otzen)

Daniel Otzen

Professor Interdisciplinary Nanoscience Center - INANO-MBG, iNANO-huset
Group members
Research funding

Research focus in brief

Our research activities fall within 3 main areas, which all relate to the study of the kinetics and thermodynamics of protein conformational changes, namely membrane protein folding, protein-detergent interactions and protein fibrillation. These areas are linked by a keen interest in understanding the mechanistic and thermodynamic behaviour of proteins in different circumstances by quantifying the strength of internal side-chain interactions as well as contacts with solvent molecules, whether it be detergents, denaturants, stabilizing salts and osmolytes or lipids. Ultimately we hope this will lead to a greater manipulative ability vis-a-vis processes of both basic, pharmaceutical and industrial relevance. The general approach is to use available spectroscopic techniques (fluorescence, CD, stopped-flow, FTIR, NMR and dynamic and static light scattering) to generate data which can be analyzed in a quantitative manner to develop models and mechanisms for conformational changes at the molecular level.  

News

An artistic rendering of RNA polymerase folding RNA origami scaffolds with two proteins. At the top right a finished scaffolding with proteins marked with the colors yellow and cyan. (Illustration: Cody Geary)

2021.06.02 | iNano

Bigger and better RNA scaffolds for organising proteins

Researchers from iNANO (Aarhus University) and Caltech have developed a method to build much larger, though still nanosize, RNA scaffolds than previously thought possible using RNA origami. The method is based on new software that has been made available online so other researchers can use it to develop biosensors, nanorobots and medicine –…

Andreas Brunsgaard Laursen, former nanoscience student, CEO, and co-founder of the spinout Danish Graphene. Photo: The Kitchen AU

2021.06.01 | iNano

Portrait: newly graduated from iNANO - now co-founder and CEO of spinout

Andreas Brunsgaard Laursen recently completed his degree in nanoscience at iNANO. Now he is CEO and co-founder of the spinout Danish Graphene together with his mentor Professor Kim Daasbjerg and Associate Professor Steen Uttrup.

Professor Anja-Verena Mudring joins the Department of Chemistry iNANO at Aarhus University. (Photo: Jørgen Weber, AU Photo)

2021.05.31 | iNano

The endless possibilities of impossible salt

This summer, Aarhus University will welcome Professor Anja-Verena Mudring when she joins the Department of Chemistry (and becomes iNANO associated). Professor Mudring is one of the world's top researchers in the field of materials research. She is one of the leaders in materials development for energy conversion, and she has made a particularly…

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